What are the main uses of 2-Chlorocinnamic Acid?
2-Chlorocinnamic acid has a wide range of uses. In the field of medicine, it is a key raw material for the preparation of a variety of drugs. Because it has a special chemical structure, it can be converted into ingredients with specific pharmacological activities through a series of reactions, or can participate in the synthesis of antibacterial and anti-inflammatory drugs, making great contributions to the treatment of diseases.
In the field of materials, it also has its uses. Or it can be used as a starting material for the synthesis of functional materials. It can be chemically modified and polymerized to obtain polymer materials with special properties, such as improving the optical and electrical properties of the materials, so that the materials can play a role in optoelectronic devices, sensors, etc.
In the fine chemical industry, 2-chlorocinnamic acid can be used as a raw material for fragrances, cosmetic additives, etc. Because of its structure, it can give products a unique aroma or specific skin care effects, which can improve product quality and market competitiveness.
In organic synthesis chemistry experiments, it is often an important reagent. Chemists use it to conduct various organic reaction research, explore new synthesis methods and routes, expand the types and application range of organic compounds, and contribute to the progress of chemical science.
What are the Physical Properties of Chlorocinnamic Acid?
2-Chlorocinnamic acid is a kind of organic compound. Its physical properties are quite specific and it has important uses in many fields.
Looking at its properties, 2-chlorocinnamic acid is white to light yellow crystalline powder at room temperature and pressure. This form is easy to store and use, and due to the characteristics of the powder, when participating in chemical reactions, it can increase the contact area with other substances, making the reaction more efficient.
When it comes to melting point, the melting point of 2-chlorocinnamic acid is about 193-197 ° C. Melting point is an important physical constant of the substance, whereby the purity of the substance can be identified. If the melting point is accurate and the melting range is narrow, it indicates that the purity of the substance is quite high; conversely, if the melting range is wide, the purity is poor.
Furthermore, 2-chlorocinnamic acid is slightly soluble in water. This solubility makes it necessary to consider its dispersibility and interaction with aqueous substances in the reaction of aqueous phase systems. However, it is soluble in organic solvents such as ethanol and ether. In the organic synthesis reaction, the selection of suitable organic solvents can effectively dissolve 2-chlorocinnamic acid, creating a good homogeneous environment for the reaction and promoting the smooth progress of the reaction.
In addition, 2-chlorocinnamic acid has certain stability. However, under certain conditions, such as high temperature, strong acid, and strong alkali environment, its structure may change, triggering chemical reactions and generating new substances. Therefore, during storage and use, it is necessary to pay attention to the influence of environmental factors on its stability, and store it properly to prevent deterioration.
In summary, the physical properties of 2-chloro cinnamic acid, such as morphology, melting point, solubility, and stability, play a crucial role in its application in chemical, pharmaceutical, and materials fields, laying the foundation for its effective use in various fields.
What are the Chemical Properties of 2-Chlorocinnamic Acids?
2-Chlorocinnamic acid is also an organic compound. It has special chemical properties and is quite important to chemists.
View its structure, containing chlorine atoms and the structure of cinnamic acid. The introduction of chlorine atoms gives this substance unique reactivity. Its acidity is derived from the carboxyl group, which can neutralize with bases under appropriate conditions to generate corresponding salts and water.
When it comes to reactivity, due to the conjugate system of the benzene ring, its electron cloud distribution is different, and it is easy to be attacked by electrophilic reagents, triggering electrophilic substitution reactions. On the aromatic ring, chlorine atoms are adjacent and para-site groups, which can affect the localization selectivity of the reaction.
And because of its carbon-carbon double bond, it can undergo addition reaction. In case of bromine water and other reagents, the double bond can be added with it to make bromine water fade. This reaction is often used for qualitative testing of double bonds.
In the field of organic synthesis, 2-chlorocinnamic acid is often an important intermediate. With its acidity and the reactivity of double bonds and phenyl rings, various organic compounds with specific functions can be prepared through various reaction paths.
In terms of solubility, it is slightly soluble in water, but soluble in common organic solvents such as ethanol, ether, etc. This solubility characteristic is crucial in the separation, purification and choice of reaction medium. In conclusion, 2-chlorocinnamic acid plays an important role in the research and practical application of organic chemistry due to its unique chemical properties.
What is the Production Method of Chlorocinnamic Acid?
The preparation method of 2-chlorocinnamic acid has been known since ancient times. In the past, the production method was mostly based on the classical organic synthesis technique.
First, cinnamic acid was used as the starting material and prepared by halogenation reaction. Dissolve cinnamic acid in suitable organic solvents, such as dichloromethane and chloroform, because of its good solubility, the reaction can be homogenized. Then, in a low temperature and dark environment, slowly add halogenating reagents, such as thionyl chloride, phosphorus trichloride, etc. This is because the halogenation reaction is easily affected by temperature and light, and the control conditions are very important. After adding it dropwise, heat it up to a moderate temperature to make the reaction sufficient. During this period, it needs to be assisted by stirring to make the material mix evenly and accelerate the reaction process. After the reaction is completed, the impurities are removed by extraction, washing, drying, distillation and other steps to obtain pure 2-chlorocinnamic acid.
Second, benzaldehyde and chloroacetic acid are used as raw materials and prepared by Perkin reaction. First, benzaldehyde, chloroacetic acid and anhydrous potassium acetate are mixed in a reaction vessel in a certain proportion, and an appropriate amount of acetic anhydride is added. This reaction needs to be carried out under heating conditions, and the temperature should be controlled at 150-170 ° C. During the reaction, potassium acetate is used as a catalyst, and acetic anhydride participates in the reaction and provides acetyl groups. After the reaction is completed, the product is cooled, acidified, filtered, recrystallized, etc., to purify the product to obtain 2-chlorocinnamic
Third, styrene derivatives are used as raw materials to obtain halogenated styrene, and then obtained by carboxylation reaction. In the reaction system, a halogenating reagent is added to halogenate the styrene derivatives to produce halogenated styrene. Subsequently, under suitable catalyst and reaction conditions, carbon dioxide is introduced and carboxylation is carried out to finally obtain 2-chlorocinnamic acid. Although this method step is complicated, the reaction conditions can be flexibly adjusted according to the characteristics and needs of the raw materials to achieve the ideal yield and purity.
What is the price range of 2-Chlorocinnamic Acid in the market?
What is the price of 2-chloro cinnamic acid in the market? This question is quite crucial, and it is related to the trade-off of business affairs. However, there is no constant price in the market, and its price often changes for many reasons.
Let's talk about the supply first. If the supply is abundant and the supply exceeds the demand, the price will be cheap. The origin is abundant, the raw materials are abundant, and the workshop production is not worried, which can increase the supply, and the price may drop to tens of yuan per kilogram. On the contrary, if the supply is scarce, the supply is in short supply, and the price will be expensive. In the event of disasters in the origin, shortages of raw materials, or obstacles to transportation, the supply can be poor, and the price may reach hundreds of yuan per kilogram.
Let's talk about quality again. Those with high quality, the price will be high. With few impurities and excellent purity, it is suitable for high-end chemical and pharmaceutical research and development. Its price is not cheap, or more than 100 yuan per kilogram. And the quality is slightly inferior and contains more impurities. It is only used in ordinary industry, and the price is relatively low, or tens of yuan per kilogram.
Look at the market demand. If the demand is strong, the price will rise. For example, the demand for it in the pharmaceutical, spice and other industries has increased greatly. Many people ask for it, and the merchants will take advantage of the trend to raise the price, and the price may rise. If the demand is low, the merchant will reduce the stock or reduce the price to promote it.
Overall, the price of 2-chloro cinnamic acid in the market ranges from tens of yuan to hundreds of yuan per kilogram. Buyers should carefully inspect the supply, quality and demand in order to obtain a suitable price.