3 Bromocinnamic Acid

3-Bromocinnamic Acid, that is, 3-bromocinnamic acid. This is an organic compound with unique chemical properties.
Its physical properties are usually solid at room temperature, with a specific melting point and boiling point. The melting point is about 200-204 ° C. At this temperature, the solid phase will gradually melt into the liquid phase. The boiling point is related to its gasification temperature. However, due to the fact that the substance is easy to decompose when heated, accurate boiling point data is difficult to measure.
In terms of chemical activity, its molecular structure contains carbon-carbon double bonds and carboxyl groups, which give it diverse reactivity. The carbon-carbon double bond can undergo an addition reaction, such as addition with bromine elemental, the double bond is broken, and bromine atoms are added to two carbon atoms to form dibromide. This reaction is often carried out quantitatively and can be used to determine the content of double bonds. And polymerization can occur. Under appropriate initiators and conditions, the double bonds are opened and connected to each other to form a polymer.
Carboxyl groups are also active and acidic in nature. They can neutralize with bases to form corresponding carboxylates and water. Esterification reactions with alcohols catalyzed by acids can occur to form esters and water. This reaction is a reversible reaction, and water often needs to be removed to promote the reaction to proceed in the direction of ester formation. < Br >
In addition, although its benzene ring is relatively stable, it can also undergo substitution reactions under specific conditions, such as halogenation, nitrification, etc. The hydrogen atom on the benzene ring can be replaced by other groups. The chemical properties of 3-bromo cinnamic acid make it widely used in the field of organic synthesis, and can be used as an important intermediate for the preparation of a variety of drugs, fragrances and functional materials.

3-Bromo cinnamic acid has a wide range of uses. In the field of medicine, it is an important raw material for the synthesis of traditional Chinese medicine. Taking the preparation of some antibacterial drugs as an example, this acid can introduce key chemical structures through specific reaction steps to enhance the antibacterial activity of the drug. Due to the specific bromine atom and cinnamic acid structure, the drug is endowed with unique chemical and biological characteristics, which can more effectively act on the target of pathogens, interfere with the metabolism of pathogens or destroy their cell structure, and then exert antibacterial effect.
In the field of materials science, 3-bromo cinnamic acid also has key uses. It can be used to prepare special functional polymer materials, such as polymers with light response properties. By chemically grafting it into the polymer backbone, the material will undergo specific structural changes under light, which makes the material have potential application value in the fields of light-controlled switches and optical storage media. When illuminated, the material structure change can realize the switch "on" and "off" state switching, or be used for information storage and reading.
Furthermore, in the field of organic synthesis chemistry, 3-bromo cinnamic acid is often used as an important intermediate. Due to its high reactivity of double bonds and bromine atoms in its molecular structure, it can participate in many classical organic reactions, such as nucleophilic substitution and addition reactions. With these reactions, chemists can skillfully construct complex organic molecular structures, opening up a broad path for the synthesis of new organic compounds, greatly promoting the development of organic synthetic chemistry, and assisting in the development of various organic compounds with unique properties and uses.

The synthesis method of 3-bromo cinnamic acid has existed in ancient times, and is described in detail below.
First, cinnamic acid is used as the starting material and prepared by bromination reaction. In the structure of cinnamic acid, the carbon-carbon double bond is relatively active and can be added to bromine. The cinnamic acid is placed in a suitable organic solvent, such as carbon tetrachloride, and bromine is slowly added dropwise at low temperature and protected from light. During this process, the reaction temperature and the dropwise acceleration of bromine need to be closely monitored. Because bromine is highly oxidizing and corrosive, the operation must be cautious. When the reaction is complete, the product can be purified by recrystallization and other methods to obtain 3-bromo cinnamic acid. < Br >
Second, benzaldehyde and malonic acid can be used as raw materials, through Knoevenagel condensation reaction, cinnamic acid can be prepared first, and then brominated. Benzaldehyde and malonic acid are catalyzed by organic bases such as pyridine under heating and refluxing conditions to produce cinnamic acid. This reaction condition is relatively mild, but the reaction time is long. After the cinnamic acid is generated, 3-bromo cinnamic acid can also be obtained by the above bromination method.
Third, styrene derivatives are used as raw materials to synthesize through a series of reactions such as halogenation, hydrolysis, and esterification. First, the styrene derivative is halogenated with a brominating reagent, bromine atoms are introduced into the side chain of the benzene ring, and then the side chain functional groups are converted into carboxylic groups by hydrolysis reaction. Finally, the side chain functional groups are further modified by esterification reaction, etc., and finally 3-bromo cinnamic acid can be obtained. This method is slightly complicated, but the raw materials are widely sourced, which is also a feasible way.
All this synthesis method has its own advantages and disadvantages. Experimenters should choose carefully according to actual needs and conditions.

3-Bromocinnamic acid is an organic compound. When storing, many things need to be paid attention to.
First environmental conditions. It should be placed in a cool place, because the temperature is too high, or it may cause chemical reactions and the structure will be damaged. If heated, it may cause changes such as decomposition, which will damage its quality. And keep it dry, because it has a certain degree of hygroscopicity, if the environment is humid, it is easy to absorb moisture, resulting in a decrease in purity, or the action of water induces reactions such as hydrolysis. Therefore, a dry and cool storage environment is the most important.
Second, packaging. Packaging must be tight to prevent excessive contact with air. Oxygen in the air may oxidize it and change its chemical properties. At the same time, avoid mixing with other chemicals, interacting with different chemicals, or triggering uncontrollable reactions. Packaging materials should also be considered, and materials that can resist corrosion and do not react with 3-bromo cinnamic acid should be used to ensure their stability.
Furthermore, do a good job of marking. Clearly indicate the name, specifications, storage conditions, hazardous characteristics and other key information for easy access and management. Warehouse personnel can follow the label to understand its characteristics, follow appropriate storage and operation practices, and reduce risks.
In addition, regular inspection is also indispensable. Check whether the package is damaged or whether the substance has deteriorated. If the package is found to be damaged, the package should be replaced in time to prevent further deterioration. Through regular inspection, the quality and safety of 3-bromo cinnamic acid can be ensured during storage.
Storage of 3-bromo cinnamic acid requires careful attention to the environment, packaging, labeling, inspection, etc., to ensure that its chemical properties are stable and its quality is not affected.

For 3-bromo cinnamic acid, it is difficult to determine the price range of its market. The price of this product often varies due to many reasons, such as the place produced, the purity of the product, the state of demand for supply, and the scenery of trade.
Looking at the past, the price of each product varies depending on the place of origin. If the product is produced in excellent land, the quality is pure and abundant, and the price is relatively flat; if the place of origin is remote and difficult to harvest, the price will increase. And the purity of the product has a great impact on the price. Pure, the price is always high; miscellaneous, the price is low. The state of demand and supply is also the main reason. When there is a demand for abundant supply, the price rises; if there is an oversupply, the price tends to fall. As for the situation of trade, the price is stable or rising when the market is good, and the price may fall when the market is weak.
In the past, the price of 3-bromo cinnamic acid per kilogram may be between hundreds and thousands of yuan. However, this is only an approximate number, and the actual price is difficult to stop here. To know the exact price, when you consult the merchants of chemical materials, or observe the real market conditions, you can get a near-real price.