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4-Fluorocinnamic Acid

Juelun Chemical

Specifications

HS Code	343806
Chemical Formula	C9H7FO2
Molar Mass	166.15 g/mol
Appearance	White to off - white solid
Melting Point	193 - 197 °C
Boiling Point	302.6 °C at 760 mmHg
Solubility In Water	Slightly soluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, methanol, chloroform
Pka	3.99
Density	1.311 g/cm³
Flash Point	136.8 °C

Packing & Storage

Packing	100g of 4 - Fluorocinnamic Acid packaged in a sealed, chemical - resistant bag.
Storage	4 - Fluorocinnamic acid should be stored in a cool, dry place, away from heat and ignition sources. Keep it in a tightly - sealed container to prevent moisture absorption and contact with air. Store it separately from incompatible substances like strong oxidizing agents. Ideal storage conditions help maintain its chemical integrity and reduce the risk of degradation or hazardous reactions.
Shipping	4 - Fluorocinnamic Acid is shipped in well - sealed, corrosion - resistant containers. Special care is taken to ensure compliance with chemical transportation regulations, protecting it from physical damage and environmental factors during transit.

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General Information

Historical Development

4-Fluorocinnamic acid is an important raw material for organic synthesis. Its origin was unknown at the beginning of the exploration of chemical experts, but in the field of organic synthesis, they gradually paid attention to this compound.
In the past, technology was not as prosperous as it is today, and the synthesis of this acid was difficult. However, the public was determined and continued to study. From the initial simple method, the yield was low and there were many impurities.
Later, with the passage of time, scientific progress, and new synthesis paths emerged. The reaction conditions gradually became milder, the yield was improved, and the purity was greatly improved. From the niche exploration in the laboratory to the occasional application in the industrial field, the development trend is clear. From the initial exploration of ignorance to the gradual refinement of skills, 4-fluorocinnamic acid has begun to exhibit its unique posture on the stage of chemistry, paving the way for more chemical research and application in the future. It is an important symbol in the long river of chemical development.

Product Overview

4 - Fluorocinnamic Acid is an organic compound. Its shape is powder, white or off-white. This substance has special chemical properties and is widely used in the field of organic synthesis.
Looking at its structure, it contains fluorine atoms and cinnamic acid skeleton, and the introduction of fluorine atoms endows it with unique physical and chemical properties. In the reaction, it is often used as a key raw material and can be used to prepare other complex organic molecules through various chemical reactions.
And 4 - Fluorocinnamic Acid has good stability. Under suitable conditions, it can be stored for a long time without easy deterioration. In pharmaceuticals, materials science, and many other fields, it has shown its important value and is valued by researchers. It has made great contributions to the exploration of new substances and new synthesis paths.

Physical & Chemical Properties

4-Fluorocinnamic Acid is an organic compound with unique physical and chemical properties. Its color is white, powdery, and stable at room temperature. When it comes to the melting point, it is between 190-193 ° C, which is helpful for identification and purification.
From the perspective of chemical properties, 4-Fluorocinnamic Acid contains carbon-carbon double bonds and carboxyl groups, so it has the commonality of olefins and carboxylic acids. Carbon-carbon double bonds can undergo addition reactions, such as addition with halogens and hydrogen halides; carboxyl groups can neutralize with bases to form corresponding carboxylates. And the presence of fluorine atoms on its benzene ring affects the electron cloud density of the benzene ring, making the electrophilic substitution reaction activity and positional selectivity different. It is widely used in the field of organic synthesis and can be used as an intermediate to prepare a variety of functional materials and drugs, making it an important organic compound.

Technical Specifications & Labeling

4-Fluorocinnamic acid is also a chemical product. Its process specifications and identification (product parameters) are the key to research.
The process of making this acid requires precise control of the ratio of raw materials and reaction under suitable temperature and pressure conditions. The utensils used must be clean and accurate to ensure a smooth reaction. During the reaction process, close monitoring and fine-tuning conditions according to changes to prevent side reactions.
Its identification (product parameters) is related to purity, impurity content, melting boiling point, etc. Those with high purity are of high quality; those with few impurities meet the needs of application. The melting boiling point is fixed, which is the proof of quality. Accurate determination of this parameter is the basis for judging the quality of the product. Adhere to process specifications and identify product parameters to obtain high-quality 4-fluorocinnamic acid for various applications.

Preparation Method

4-Fluoro-cinnamic acid is an organic compound. The preparation method, raw materials and production process, reaction steps, and catalytic mechanism are all essential for preparation.
To prepare 4-fluoro-cinnamic acid, many people use 4-fluorobenzaldehyde and malonic acid as raw materials. Under the catalysis of pyridine, the two perform Knoevenagel condensation reaction. The temperature of this reaction should be controlled at a moderate level. If it is too high, it will be vice-reflexive, and if it is too low, the reaction will be slow.
For the reaction step, first put 4-fluorobenzaldehyde and malonic acid in a certain proportion into the reactor, and add an appropriate amount of pyridine as catalysis. Stir well and gradually heat up. To observe the reaction process, the instrument measured, after the completion of the reaction, separation and purification of art, can be obtained pure 4-fluorocinnamic acid.
Catalytic mechanism, pyridine can activate malonic acid, making it easier to react with 4-fluorobenzaldehyde, reduce the energy barrier of the reaction, promote the reaction to obtain 4-fluorocinnamic acid product.

Chemical Reactions & Modifications

Today there are 4 - Fluorocinnamic Acid. We should investigate in detail the chemical reaction and modification. Its chemical properties are related to various reactions, or can be changed according to different conditions.
To understand its reaction, it is necessary to observe its structure and investigate its bonding. Look at the arrangement of its atoms and think about the cloud movement of its electrons. There may be a nucleophilic reaction or an electrophilic activity, depending on the conformation of its molecules.
As for the way of modification, you can use chemical methods to add groups and change the structure. Or introduce functional groups to change their physical properties, such as the point of melting and the degree of dissolution; or adjust their chemical properties to make them have new activities for other synthesis.
We should use scientific methods and rigorous hearts to explore the wonders of 4-Fluorocinnamic Acid in chemical reactions and modifications, hoping to gain new knowledge, expand the field of chemistry, and add new materials for practical use.

Synonyms & Product Names

4 - Fluorocinnamic Acid is also a chemical substance. It is the same as 4-fluorocinnamic acid, such as 4-fluorocinnamic acid, which is named after the same name as the product name. As for the trade name, or according to different countries and uses.
This substance is often explored by researchers in the field of chemical research. Its properties and synthesis methods are of great importance to research. 4 - Fluorocinnamic Acid has a variety of characteristics due to its special chemical properties. It is useful for synthesis and other aspects. For synthesis, it is necessary to pay attention to many components, such as reaction degree and catalysis. Understanding the same trade name will help researchers in different cultures and markets to clarify the relationship between this substance, so that research and application can be promoted.

Safety & Operational Standards

4 - Fluorocinnamic Acid Product Safety and Operation Specifications
Fu 4 - Fluorocinnamic Acid, a product of chemistry. Safety and standard operation are of paramount importance during its preparation, use and storage.
When preparing, all reagents and instruments should be treated with caution. The reagents used must be carefully checked for their properties, especially if they are flammable, explosive or toxic. The operation room should be well ventilated to prevent the accumulation of harmful gases. And all kinds of instruments must be kept clean and intact before they can be activated.
When using, the experimenter should wear suitable protective equipment, such as laboratory clothes, gloves, goggles, etc., to protect against possible hazards. When taking 4 - Fluorocinnamic Acid, the action should be slow and avoid dust to prevent inhalation or contact with skin and eyes. In case of accidental contact, rinse with plenty of water immediately and seek medical attention according to the situation.
In terms of storage, 4 - Fluorocinnamic Acid should be placed in a cool, dry and ventilated place, away from fire sources and oxidants. Different batches of products should be stored in categories and clearly marked for easy search and management.
Furthermore, during the entire operation process, the established operation steps should be strictly followed and no unauthorized changes should be made. After each step of operation, the results should be checked. If there is any abnormality, stop the operation immediately to find out the reason.
In conclusion, the safety and standardized operation of 4 - Fluorocinnamic Acid is related to the safety of the experimenter and the success or failure of the experiment. It is necessary to maintain a rigorous attitude and follow the rules to ensure that everything goes smoothly.

Application Area

4-Fluorocinnamic acid has a unique nature and is widely used. In the field of medicine, it can be used as a medicine, or to help regulate qi and blood, and heal injuries and diseases. It has a mild nature, can pass through meridians and collaterals, reduce stasis, and is beneficial in the treatment of diseases.
In the industry of dyeing and weaving, it also has strengths. It can be used as a color agent. The dye fabric has a bright color, and the color fastness is good, and it will not fade over time. Make clothes and silk bright and increase their appearance.
In the manufacture of fragrances, 4-fluorocinnamic acid is also a good material. It can give a unique fragrance, fresh and elegant, and can add a different style to fragrance products, pleasing to people's sense of smell.
From this perspective, the use of 4-fluorocinnamic acid spans the fields of medicine, dyeing and weaving, and fragrances, and is truly valuable.

Research & Development

In recent times, the art of chemistry has become more and more refined, and the research of substances has been almost advanced. 4 - Fluorocinnamic Acid This thing has been studied by scholars for years. Its structure is specific, its properties are unique, and it is of great use in the fields of chemical industry and medicine.
Zhu Xian worked hard to explore the method of its synthesis. At the beginning, the path was difficult, and the yield was quite low. However, everyone was unswerving, and it lasted for a long time. After repeated trials and errors, the process was improved, and the yield gradually increased.
At the same time, the exploration of its application has not been slack. In medicine, it can help develop new agents to fight various diseases; in the chemical field, it can improve the color of materials. From this point of view, the research and development of 4 - Fluorocinnamic Acid has a broad prospect and will surely contribute to the progress of the world and benefit all beings.

Toxicity Research

This study 4 - Toxicology of Fluorocinnamic Acid. This material nature is different, and it is related to many things. To understand its toxicity, many methods need to be applied. First, take the animal as a test, observe its state after taking it, and observe the changes in its diet, movement and lying, and physical symptoms. Furthermore, study the path of its entry into the body, oral, percutaneous or respiratory inhalation, are different. Also explore its transformation in the body, know its metabolic path, and know where it accumulates. After such inquiries, hope that the toxicology of 4 - Fluorocinnamic Acid is safe to use, avoid its harm, protect the health of the public, and protect the peace of the environment. It is also an important task for this toxicity study.

Future Prospects

4 - Fluorocinnamic Acid is also a transformative thing. Today, we are full of hope for our future prospects. In the field of technology, there may be new breakthroughs, ways to help research special effects, and save the world. In the field of materials, it may be a new light, into a material with excellent performance, and it can be used widely. And its synthesis method is exquisite in the day, cost is reduced, and quantity is promising. In the future, 4 - Fluorocinnamic Acid will be like the best of the world, showing its skills in various fields, adding more and more tiles, creating limited possibilities, and leading us to a bright future.

Frequently Asked Questions

What are the main uses of 4-Fluorocinnamic Acid?

4-Fluorocinnamic acid has a wide range of uses. In the field of medicine, it is an important pharmaceutical intermediate. For example, in the synthesis of many cardiovascular disease drugs, it is often used as a starting material. Due to its unique chemical structure, it can be converted into compounds with specific pharmacological activities through a series of reactions, helping to regulate the physiological functions of the cardiovascular system, or used in the development of drugs to lower blood pressure and prevent arrhythmia.
In the field of materials science, it also shows extraordinary value. In the preparation of some functional polymer materials, 4-fluorocinnamic acid can participate in the polymerization reaction, giving the material special properties. If the material has specific optical properties, it is used for the preparation of photoresponsive materials. When stimulated by light, the material structure or properties change, which is very useful in the field of light-controlled switches and sensors.
In the field of organic synthesis, this is a key synthetic building block. With its double bond and fluorine atom properties, it can carry out a variety of organic reactions, such as addition reactions with nucleophiles, or reactions such as oxidation and reduction into other important organic compounds, providing a foundation for the construction of complex organic molecules, expanding the research boundaries of organic synthesis chemistry, and promoting the development of organic synthesis technology.

What are the Physical Properties of 4-Fluorocinnamic Acid?

4-Fluorocinnamic acid is also an organic compound. It has specific physical properties, which are described in detail by you today.
Looking at its appearance, it is often white to light yellow crystalline powder, which is observable by eye. As for the melting point, it is about 248-250 ° C. When the temperature reaches this point, the substance gradually melts from a solid state to a liquid state. The temperature of this phase transition is crucial for its identification and purification.
In terms of solubility, 4-fluorocinnamic acid is slightly soluble in water. Water is the source of all things, and many substances interact with it. And 4-fluorocinnamic acid dissolves very little in water, but it is soluble in some organic solvents, such as ethanol, ether, etc. Ethanol, a common organic solvent, is volatile and soluble, and 4-fluorocinnamic acid can be dissolved in it. This property is used in organic synthesis and related experimental operations to facilitate the steps of dissolution, separation and purification.
Furthermore, 4-fluorocinnamic acid has certain stability, and under conventional conditions, it is not easy to undergo violent chemical reactions to cause its structure to change. However, under specific conditions, such as strong acids, strong bases or high temperatures, strong oxidants, etc., the double bonds, carboxyl groups and fluorine atoms in its structure may react, causing structural changes and generating new compounds.
Its density is also one of the important physical properties. Although the exact value varies depending on the measurement conditions, it is roughly within a certain range. The value of density is related to its distribution in the mixture and related physical processes. It is used in chemical production, material preparation and other fields to consider the proportion of materials and the mixing effect.
In summary, the physical properties of 4-fluorocinnamic acid, such as appearance, melting point, solubility, stability and density, are of great significance in organic chemistry research, chemical production and related fields, laying the foundation for its application and in-depth research.

Is 4-Fluorocinnamic Acid Chemically Stable?

4-Fluorocinnamic acid, the stability of its chemical properties is the focus of many researchers. This substance, in the field of chemistry, has alkenyl and carboxyl groups, and fluorine atoms are substituted on the benzene ring.
From the perspective of its structure, the presence of alkenyl groups makes it unsaturated and can participate in addition reactions, such as addition with electrophilic reagents, which makes the part of the structure in an active state and affects its overall stability. Carboxyl groups are acidic and can neutralize with bases. Due to the electron-withdrawing effect of carboxyl groups, it also affects the electron cloud distribution of the benzene ring, indirectly affecting the chemical behavior of the entire molecule.
Fluorine atoms are substituted in the benzene ring. Due to the large electronegativity of fluorine, its induction effect is strong, which can change the electron cloud density of the benzene ring and affect the activity of electrophilic substitution reaction. Although it can reduce the electron cloud density of the benzene ring, which is slightly more difficult than benzene in the electrophilic substitution reaction, it also stabilizes the benzene ring structure to a certain extent due to the existence of fluorine atoms.
However, when it comes to stability, 4-fluorocinnamic acid is relatively stable under normal conditions without the influence of special reagents or environmental factors. When exposed to high temperatures, strong acid bases or specific catalysts, its active sites such as alkenyl groups and carboxyl groups will react, causing its structure to change. For example, in a strongly acidic environment, the carboxyl group may protonate, which affects the intermolecular force; in a high temperature and aerobic environment, the alkenyl group may undergo oxidation reaction.
In short, the stability of 4-fluorocinnamic acid is not absolute, and it varies depending on the environment and conditions. It can maintain a relatively stable state in conventional chemical operations and storage environments, but under specific conditions, its chemical activity will be revealed, triggering corresponding chemical reactions.

What are the Synthetic Methods of 4-Fluorocinnamic Acid

The synthesis method of 4-fluoro-cinnamic acid is not detailed in ancient books, but there are many ways based on today's chemical knowledge and synthetic technology.
First, 4-fluorobenzaldehyde and malonic acid are used as raw materials, which is a classic Knoevenagel condensation reaction. Under the catalysis of organic bases such as pyridine, the two condensate and decarboxylate to obtain 4-fluoro-cinnamic acid. This reaction conditions are mild, the operation is relatively simple, and the yield is relatively considerable. During the reaction, 4-fluorobenzaldehyde and malonic acid are placed in a reactor in a certain proportion, an appropriate amount of pyridine is added, and the reaction is stirred at a suitable temperature. After the reaction is completed, pure 4-fluorocinnamic acid can be obtained through extraction, washing, recrystallization and other steps.
Second, 4-fluorostyrene is used as the starting material, and is prepared by bromination, hydrolysis, oxidation and other multi-step reactions. First, 4-fluorostyrene and bromine undergo an addition reaction to obtain 1,2-dibromo-4-fluorophenylethane, and then hydrolyze under alkaline conditions to generate 4-fluorophenylethanol, which is then oxidized, such as oxidation with potassium permanganate and other oxidants, and finally 4-fluorocinnamic acid can be obtained. This route step is slightly complicated, but the raw material is easy to obtain, and the reaction mechanism of each step is clear, which is conducive to control.
Third, the product can be obtained by reacting 4-fluorobenzoyl chloride with vinyl Grignard reagent, and then dehydrating and other treatments. This method requires anhydrous and anaerobic conditions, which requires high operation requirements. However, it can effectively construct the carbon-carbon double bond structure of the target molecule, which is quite valuable under specific conditions.
All synthesis methods have advantages and disadvantages, and the choice needs to be weighed according to the availability of raw materials, the difficulty of reaction conditions, cost-effectiveness and other factors to achieve the optimal synthesis effect.

What is the price range of 4-Fluorocinnamic Acid in the market?

4-Fluorocinnamic acid is on the market, and its price range is quite difficult to determine. This price often varies due to various factors, such as the purity of the product, the process of preparation, the number of purchases, and the supply and demand situation of the market.
In the past, in ordinary business markets, if the purity of 4-fluorocinnamic acid is about 98%, the price per gram can be sold in small quantities, or in the range of tens of yuan. If the bulk purchase, the quantity reaches more than kilograms, the price per gram may be reduced to more than ten yuan due to economies of scale.
However, the chemical market is changing, and the price of raw materials fluctuates and fluctuates, which also deeply affects the price of 4-fluorocinnamic acid. If the raw materials required for its preparation are scarce and the price rises, the price of the finished product will also rise. And produced by different origins and manufacturers, due to differences in process, the quality is different, and the price is also different. Most of the well-known large factories have fine craftsmanship and strict quality control, and their product prices may be high; while the products of small factories may be cheap, but the purity and stability may be inferior.
In addition, the supply and demand relationship of the city is also the key. If there are many people who need it at a time, but the supply is limited, the price will rise; conversely, if there is more production and less demand, the price may drop. Therefore, if you want to know the exact price, it is advisable to consult the chemical product supplier, or check the real-time market in detail on the chemical trading platform, in order to get a near-real price.